GENOTOXIC IMPURITIES: AN IMPORTANT REGULATORY ASPECT
نویسندگان
چکیده
منابع مشابه
Genotoxic Impurities in Pharmaceuticals
Genotoxic compounds induce genetic mutations and/or chromosomal rearrangements and can therefore act as carcinogenic compounds (McGovern and Jacobson-Kram, 2006). These compounds cause damage to DNA by different mechanisms such as alkylation or other interactions that can lead to mutation of the genetic codes. In general, chemists employ the terms "genotoxic" and "mutagenic" synonymously; howev...
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tein metabolism (H. N. Munro, ed.). Academic Press, New York. MARTIN, A. P., AND S. R. PALUMBI. 1993. Body size, metabolic rate, generation time, and the molecular clock. Proc. Natl. Acad. Sci. USA 90:4087–4091. NEI, M., AND W.-H. LI. 1979. Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc. Natl. Acad. Sci. USA 76:5269– 5273. RAND, D. M. 1994. Thermal...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2020
ISSN: 2455-3891,0974-2441
DOI: 10.22159/ajpcr.2020.v13i6.37370